| Expression pattern: |
UP |
| Associated gene: |
HMGB3, beta-catenin, c-Myc, cyclin D1, HK2, Wnt/beta-catenin pathway |
| Associated microRNA: |
miR-362-5p |
| Biological function: |
Circ-IGF1R functions as an oncogenic factor in CRC by promoting proliferation, migration, invasion, glycolysis and tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
Circ-IGF1R acts as a miR-362-5p sponge to upregulate HMGB3 and activate the Wnt/beta-catenin pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-IGF1R expression predicts poor prognosis in CRC patients; circ-IGF1R might be a diagnostic and therapeutic target for CRC. |
| Description: |
Circ-IGF1R is up-regulated in colorectal cancer tissues and cell lines and is associated with poorer overall survival. Functionally, circ-IGF1R promotes CRC cell proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a miR-362-5p sponge to enhance HMGB3 expression and activate the Wnt/beta-catenin pathway. |
| Confidence score: |
0.8861 |