| Expression pattern: |
UP |
| Associated gene: |
ALDH1A3, AGO2, PI3K/AKT/mTOR signaling pathway |
| Associated microRNA: |
miR-1301-3p |
| Biological function: |
promotes docetaxel resistance and suppresses docetaxel chemosensitivity; inhibits DTX-induced apoptosis and reduces G2/M phase arrest |
| Molecular mechanism: |
circCYP24A1 acts as a miRNA sponge for miR-1301-3p to upregulate ALDH1A3 and activate PI3K/AKT/mTOR signaling, promoting docetaxel resistance |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); apoptosis (inhibits); cell cycle (other); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; TUNEL; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circCYP24A1 expression was an independent risk factor to predict DTX response and could be a biomarker to predict DTX response |
| Description: |
circCYP24A1 is upregulated in docetaxel-resistant prostate cancer and reduces DTX chemosensitivity in vitro and in vivo. It promotes chemoresistance by sponging miR-1301-3p to upregulate ALDH1A3 and activate PI3K/AKT/mTOR signaling, and its expression predicts DTX response in a patient cohort. |
| Confidence score: |
0.8932 |