| Expression pattern: |
UP |
| Associated gene: |
SOAT1, AGO2 |
| Associated microRNA: |
miR-30a-3p |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, tumor growth and lung metastasis; increases total cholesterol (T-CHO) and low-density lipoprotein cholesterol (LDL-C) levels. |
| Molecular mechanism: |
ceRNA/miRNA sponge: circLDLR competitively binds miR-30a-3p, relieving repression of SOAT1 and promoting malignant progression; associated with AGO2-RISC binding. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); lipid metabolism (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High circLDLR expression is associated with malignant progression/TNM stage and predicts poor prognosis (poorer overall survival) in CRC patients. |
| Description: |
circLDLR is up-regulated in colorectal cancer and promotes malignant progression (proliferation, migration/invasion, tumor growth and lung metastasis). It acts as a ceRNA by sponging miR-30a-3p to increase SOAT1 expression, which is linked to elevated cellular cholesterol (T-CHO and LDL-C). High circLDLR expression correlates with advanced clinical features and poorer overall survival. |
| Confidence score: |
0.8932 |