circRNA basic information
circBase ID: hsa_circ_0006470
Name: -
Synonym: hsa-circ-0006470
Host Gene: -
Genomic location(hg19): chr1:12061457-12062160:+
Genomic location(hg38): chr1:12001400-12002103:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

GES-1; AGS; MKN45; SNU5
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: TP53I11
Associated microRNA: miR-1234
Biological function: inhibits viability and proliferation; inhibits migration; induces G1 cell cycle arrest
Molecular mechanism: hsa_circ_0006470 binds miR-1234 to relieve repression of TP53I11, affecting downstream Akt/FOXO1/CDK2-related signaling and cell cycle progression
Biological pathway or process:

proliferation (inhibits); migration (inhibits); cell cycle (inhibits); PI3K/AKT (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Cell Cycle Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

In gastric cancer cell lines, hsa_circ_0006470 is down-regulated and mainly localized in the cytoplasm. Its overexpression suppresses viability/proliferation and migration and induces G1 arrest. Mechanistically, it acts as a miR-1234 sponge to increase TP53I11 expression, with downstream changes consistent with inhibition of AKT signaling (reduced p-Akt) and cell-cycle regulators (reduced CDK2, increased FOXO1).
Confidence score:

0.6737
Other information
Title:

Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells via regulation of miR-1234/TP53I11 axis.

Journal: European journal of histochemistry : EJH
Published: 2022
PubMed ID: 36190397
Study type:

biological research
Data availability: -
Code availability: -