circRNA basic information
circBase ID: -
Name: hsa_circ_ABCC1
Synonym: circABCC1
Host Gene: ABCC1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005010
MONDO name: coronary artery disorder
Disease details: coronary artery disease / CAD
Disease DO ID:
 3393
Disease MeSH ID:
 D003324
Disease NCIt ID:
 C26732
Disease ICD11 ID:
 1059873720
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: hsa-miR-34a, hsa-miR-34c, hsa-let-7b, hsa-let-7i
Biological function: Proposed to promote endothelial cell dysfunction in CAD by modulating CAD-associated miRNAs (miRNA sponge/ceRNA role).
Molecular mechanism: Putative miRNA sponge/ceRNA mechanism; CAD GWAS variant rs12691049 may disrupt circABCC1 and alter EC-specific gene regulation.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

This study implicates circABCC1 as a CAD-related circRNA potentially affected by variant rs12691049 and proposes that it promotes endothelial dysfunction by modulating miRNAs including hsa-miR-34a/34c and hsa-let-7b/7i.
Confidence score:

0.1768
Other information
Title:

Comprehensive analysis of non-coding RNA-mediated endothelial cell-specific regulatory circuits in coronary artery disease risk.

Journal: Frontiers in genetics
Published: 2025
PubMed ID: 40061128
Study type:

bioinformatics study
Data availability: GSE115733; GSE23561; https://www.frontiersin.org/articles/10.3389/fgene.2025.1559798/full#supplementary-material
Code availability: -