circRNA basic information
circBase ID: hsa_circ_0020394
Name: hsa_circ_DOCK1
Synonym: -
Host Gene: DOCK1
Genomic location(hg19): chr10:128768965-128860040:+
Genomic location(hg38): chr10:126970701-127061776:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder carcinoma
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; normal bladder tissue / non‐tumour tissues
Cell lines:

SVHUC‐1; BIU‐87; EJ‐m3 / EJ‐M3; T24; 5637; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: Sox5, Ago2
Associated microRNA: hsa‐miR‐132‐3p
Biological function: Promotes bladder carcinoma cell viability, proliferation and migration, and promotes xenograft tumour growth.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for hsa-miR-132-3p to regulate Sox5 expression (circDOCK1/hsa-miR-132-3p/Sox5 axis).
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Western Blot; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Transwell Assay; In Vivo Animal Model
Clinical significance:

Potential biomarker and therapeutic target for bladder carcinoma.
Description:

circDOCK1 (hsa_circ_0020394), derived from DOCK1, is up-regulated in bladder carcinoma tissues/cell lines and promotes malignant phenotypes (viability, proliferation, migration) and xenograft growth. Mechanistically, it functions as a miRNA sponge for hsa-miR-132-3p, relieving repression of Sox5 and forming the circDOCK1/miR-132-3p/Sox5 ceRNA axis.
Confidence score:

0.6783
Other information
Title:

Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway.

Journal: Cell proliferation
Published: 2019
PubMed ID: 30983072
Study type:

combined biological and clinical study
Data availability: -
Code availability: -