circRNA basic information
circBase ID: -
Name: -
Synonym: circSC25
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

Hepa1-6; HUVEC
In vivo animal model:

syngeneic model
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: miR-25
Biological function: Inhibits invasion/metastasis/migration, EMT, proliferation and angiogenesis of HCC cells via miR-25 silencing; suppresses tumor growth in vivo.
Molecular mechanism: miRNA sponge mechanism targeting miR-25.
Biological pathway or process:

proliferation (inhibits); invasion (inhibits); migration (inhibits); EMT (inhibits); angiogenesis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

Transfection; RT-qPCR; Western Blot; Transwell Assay; Wound Healing Assay; EdU Staining; In Vivo Animal Model; IHC (Immunohistochemistry); IF (Immunofluorescence)
Clinical significance:

-
Description:

circSC25 is an artificial circRNA designed to sponge/silence miR-25. In HCC models, it inhibits malignant behaviors including proliferation, invasion/migration, EMT, and angiogenesis, and suppresses tumor progression in vivo.
Confidence score:

0.5442
Other information
Title:

Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progression.

Journal: Frontiers in immunology
Published: 2025
PubMed ID: 40568595
Study type:

biological research
Data availability: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609165/full#supplementary-material
Code availability: -