| Expression pattern: |
UP |
| Associated gene: |
FOXM1, Ago2, beta-catenin, C-myc, MMP2, MMP9, E-cadherin, N-cadherin |
| Associated microRNA: |
miR-320a, miR-320b |
| Biological function: |
promotes proliferation, migration and EMT; inhibits apoptosis; promotes in vivo tumor growth |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-320a/miR-320b, thereby upregulating FOXM1 and activating Wnt signaling (beta-catenin nuclear localization). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); EMT (promotes); apoptosis (inhibits); Wnt/beta-catenin (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; TUNEL; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
potential biomarker for OS treatment |
| Description: |
circ-FOXM1 is up-regulated in osteosarcoma cell lines and promotes proliferation, migration, EMT and tumor growth while suppressing apoptosis. Mechanistically, it functions as a ceRNA to sponge miR-320a/miR-320b, elevating FOXM1 and activating the Wnt/beta-catenin pathway. |
| Confidence score: |
0.7797 |