circRNA basic information
circBase ID: hsa_circ_0006168
Name: hsa_circ_CNOT6L
Synonym: -
Host Gene: CNOT6L
Genomic location(hg19): chr4:78694234-78697546:-
Genomic location(hg38): chr4:77773080-77776392:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005277
MONDO name: migraine disorder
Disease details: Migraine
Disease DO ID:
 6364
Disease MeSH ID:
 D008881
Disease NCIt ID:
 C89715
Disease ICD11 ID:
 669367341
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood; TNC
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: KDM6B
Associated microRNA: miR-99b-5p
Biological function: promotes central sensitization; promotes microglial activation
Molecular mechanism: ceRNA mechanism by sponging miR-99b-5p to relieve repression of KDM6B
Biological pathway or process:

PI3K/AKT (promotes); immune regulation (promotes); inflammation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

In migraine, hsa_circ_0006168 is up-regulated in patients’ peripheral blood and is implicated in promoting central sensitization. Mechanistically, it acts as a ceRNA to sponge miR-99b-5p, relieving repression of KDM6B, which is linked to microglial activation in the TNC and PI3K/AKT signaling activation.
Confidence score:

0.6193
Other information
Title:

hsa_circ_0006168 drives microglial activation in TNC via miR-99b-5p/KDM6B axis to promote central sensitization in migraine.

Journal: The journal of headache and pain
Published: 2026
PubMed ID: 41654728
Study type:

combined biological and clinical study
Data availability: -
Code availability: -