| Expression pattern: |
UP |
| Associated gene: |
PAI-1 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
circPVT1 promotes HCC cell viability and clone formation, counteracting miR-145-5p-mediated suppression of proliferation. |
| Molecular mechanism: |
ceRNA mechanism: circPVT1 sponges miR-145-5p and regulates PAI-1 expression in HCC cells. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Bioinformatics Analysis |
| Clinical significance: |
The circPVT1/miR-145-5p/PAI-1 axis may provide a new biomarker for diagnosis and a therapeutic target for HCC. |
| Description: |
circPVT1 is up-regulated in HCC tissues and cell lines. It directly binds miR-145-5p and promotes HCC cell proliferative ability and clone formation, likely through the circPVT1/miR-145-5p/PAI-1 regulatory axis, suggesting diagnostic or therapeutic relevance. |
| Confidence score: |
0.6369 |