| Expression pattern: |
UP |
| Associated gene: |
APPBP2, Ago2 |
| Associated microRNA: |
miR-217 |
| Biological function: |
promotes colony formation, migration and invasion (metastasis) and inhibits apoptosis; promotes tumorigenesis in vivo; promotes EMT |
| Molecular mechanism: |
ceRNA mechanism: circBIRC6 acts as a miR-217 sponge to increase APPBP2 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circBIRC6 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation/colony formation, migration/invasion/EMT, and tumor growth while inhibiting apoptosis by sponging miR-217 to upregulate APPBP2. |
| Confidence score: |
0.7631 |