circRNA basic information
circBase ID: hsa_circ_0048122
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr19:1011578-1011662:-
Genomic location(hg38): chr19:1011579-1011663:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRCLM tissues; primary CRC tissues; early-stage CRC tissues; adjoining non-tumorous tissues (ANT)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with liver metastasis risk and poor survival in colorectal cancer; suggested oncogenic role in CRC.
Molecular mechanism: -
Biological pathway or process:

metastasis (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

High hsa_circ_0048122 is associated with liver metastasis and predicts poor overall survival in stage IV CRCLM; high expression predicts poor liver metastasis-free survival (LMFS) in early-stage CRC and may serve as a biomarker to predict metachronous liver metastasis.
Description:

hsa_circ_0048122 is up-regulated in CRC tumor tissues and further elevated in liver metastases compared with primary CRC. High expression is associated with higher liver metastasis risk and predicts worse OS in CRCLM and worse LMFS in early-stage CRC, supporting its use as a biomarker for metachronous liver metastasis prediction.
Confidence score:

0.5339
Other information
Title:

Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early-stage colorectal cancer.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35792043
Study type:

combined biological and clinical study
Data availability: GSE147597; GSE158695
Code availability: -