| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-514a-5p |
| Biological function: |
Promotes thyroid cancer cell proliferation, migration, invasion, and tumor growth; facilitates metastasis-related behaviors. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-514a-5p; miR-514a-5p inhibition rescues the effects of circ-ZNF609 knockdown. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ-ZNF609 is up-regulated in thyroid cancer cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration/invasion and xenograft tumor growth mainly by sponging miR-514a-5p, as supported by luciferase binding and rescue experiments with miR-514a-5p inhibition. |
| Confidence score: |
0.6544 |