| Expression pattern: |
UP |
| Associated gene: |
HMGA2 |
| Associated microRNA: |
miR-203 |
| Biological function: |
Promotes malignant phenotypes (proliferation, colony formation, migration, invasion, tumor growth) and promotes docetaxel (DTX) resistance; inhibits apoptosis when expressed. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-203, relieving miR-203-mediated repression of HMGA2, thereby promoting malignancy and DTX resistance. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circTHSD4 expression predicts dismal prognostic outcome and is correlated with tumor stage, lymph node metastasis, Gleason score, PSA level, and metastasis. |
| Description: |
circTHSD4 (hsa_circ_0005203), derived from THSD4, is up-regulated in prostate cancer and mainly localized in the cytoplasm. It promotes proliferation/migration/invasion and xenograft tumor growth and increases docetaxel resistance by sponging miR-203 to upregulate HMGA2; high expression is associated with poorer overall survival. |
| Confidence score: |
0.8557 |