| Expression pattern: |
UP |
| Associated gene: |
TM4SF1 |
| Associated microRNA: |
hsa-miR-330-5p, hsa-miR-4656, hsa-miR-6829-3p, hsa-miR-103a-3p, hsa-miR-107, hsa-miR-4688, hsa-miR-7161-3p, hsa-miR-3192-5p, hsa-miR-3620-5p, hsa-miR-1182, hsa-miR-6783-3p |
| Biological function: |
might contribute to the development of BPD |
| Molecular mechanism: |
ceRNA mechanism via hsa-miR-103a-3p to regulate TM4SF1 |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other); angiogenesis (other); proliferation (other); migration (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
Exosomal hsa_circ_0086913 was upregulated in umbilical cord blood exosomes from preterm infants with BPD (validated by qRT-PCR). Bioinformatic ceRNA prediction suggested a potential hsa_circ_0086913/hsa-miR-103a-3p/TM4SF1 axis that may contribute to BPD development. |
| Confidence score: |
0.4032 |