circRNA basic information
circBase ID: hsa_circ_0087302
Name: hsa_circ_TLE4
Synonym: circ-0087302
Host Gene: TLE4
Genomic location(hg19): chr9:82319697-82324614:+
Genomic location(hg38): chr9:79704782-79709699:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

hFOB1.19; HOS; MG63; U2OS; 143B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: beta-catenin, cyclin D1, Dvl 2, Dvl 3, CD44, LRP 6, LEF 1, Axin, c-Myc, c-Jun
Associated microRNA: -
Biological function: Inhibits proliferation, colony formation, cell cycle progression, migration, and invasion of osteosarcoma cells.
Molecular mechanism: Overexpression suppresses Wnt/beta-catenin signaling (reduced beta-catenin pathway proteins; increased Axin), leading to reduced malignant phenotypes.
Biological pathway or process:

Wnt/beta-catenin (inhibits); proliferation (inhibits); cell cycle (inhibits); migration (inhibits); invasion (inhibits)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0087302 is down-regulated in osteosarcoma cells. Its overexpression suppresses osteosarcoma malignant behaviors (proliferation, G0/G1 cell-cycle progression, migration, invasion), at least in part by inhibiting Wnt/beta-catenin signaling (decreasing beta-catenin and multiple downstream targets while increasing Axin).
Confidence score:

0.5997
Other information
Title:

Hsa_circ_0087302, a circular RNA, affects the progression of osteosarcoma via the Wnt/beta-catenin signaling pathway.

Journal: International journal of medical sciences
Published: 2022
PubMed ID: 36035366
Study type:

biological research
Data availability: -
Code availability: -