circRNA basic information
circBase ID: hsa_circ_0067641
Name: hsa_circ_ATR
Synonym: -
Host Gene: ATR
Genomic location(hg19): chr3:142232342-142232480:-
Genomic location(hg38): chr3:142513500-142513638:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal cervical tissues
Cell lines:

HeLa
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Associated with SCT-mediated inhibition of proliferation and promotion of apoptosis in HeLa cells.
Molecular mechanism: SCT treatment downregulates circATR expression in HeLa cells; downstream mechanism (e.g., ceRNA) not specified for circATR.
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); cell cycle (inhibits)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Transfection; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

In HeLa cervical cancer cells, SCT treatment decreases circATR expression in a dose-dependent manner. The study links SCT-modulated circATR (together with other circRNAs) to reduced proliferation, cell-cycle arrest, and increased apoptosis.
Confidence score:

0.5416
Other information
Title:

The Pharmacological Effects of Spatholobi Caulis Tannin in Cervical Cancer and Its Precise Therapeutic Effect on Related circRNA.

Journal: Molecular therapy oncolytics
Published: 2019
PubMed ID: 31194163
Study type:

combined biological and clinical study
Data availability: TCGA; GEO: GSE63514
Code availability: -