circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3 / circular Homeodomain Interacting Protein Kinase 3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma extracellular vesicle-enriched samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-149, mir-124
Biological function: promotes proliferation; inhibits apoptosis
Molecular mechanism: dual activity over miR-149 and mir-124
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circHIPK3 is up-regulated in plasma EV-enriched samples from early-stage NSCLC patients and its expression/junction was validated by RT-qPCR with divergent primers and Sanger sequencing. The article contextualizes circHIPK3 as acting via miR-149 and mir-124 and being associated with increased proliferation and reduced apoptosis in lung cancer.
Confidence score:

0.5841
Other information
Title:

Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.

Journal: Pharmaceutics
Published: 2022
PubMed ID: 36297470
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author (carlospedraz@icloud.com) upon reasonable request.
Code availability: -