circRNA basic information
circBase ID: hsa_circ_0001461
Name: hsa_circ_FAT1
Synonym: -
Host Gene: FAT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

U373; SW1783
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MYBL2
Associated microRNA: miR-30e-5p
Biological function: Promotes glioma cell proliferation, migration, and invasion.
Molecular mechanism: Acts as a miRNA sponge for miR-30e-5p, thereby increasing MYBL2 expression (ceRNA-like regulation).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay
Clinical significance:

-
Description:

circFAT1(e2) is up-regulated in glioma cell lines and promotes proliferation, migration, and invasion. It functions through a ceRNA mechanism by sponging miR-30e-5p, thereby increasing MYBL2 expression and facilitating glioma progression.
Confidence score:

0.5416
Other information
Title:

Circular RNA circFAT1(e2) Facilitates Cell Progression through the miR-30e-5P/MYBL2 Pathway in Glioma.

Journal: Disease markers
Published: 2023
PubMed ID: 36776924
Study type:

combined biological and clinical study
Data availability: TCGA
Code availability: -