| Expression pattern: |
UP |
| Associated gene: |
YWHAZ, GLUT1, HK2 |
| Associated microRNA: |
miR-1294 |
| Biological function: |
promotes cell proliferation, migration, invasion and glycolysis, and inhibits apoptosis in cervical cancer |
| Molecular mechanism: |
acts as a miRNA sponge (ceRNA) for miR-1294 to regulate YWHAZ expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Nuclear-Cytoplasmic Fractionation; Western Blot; In Vivo Animal Model; Clinical Sample Validation; RNA-seq |
| Clinical significance: |
- |
| Description: |
circCDK17 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes and glycolysis. Mechanistically, it functions as a ceRNA by sponging miR-1294 to increase YWHAZ expression, thereby enhancing proliferation/migration/invasion and reducing apoptosis; circCDK17 knockdown suppresses tumor growth in a HeLa xenograft model. |
| Confidence score: |
0.7893 |