circRNA basic information
circBase ID: hsa_circ_0004543
Name: -
Synonym: circ_0004543
Host Gene: -
Genomic location(hg19): chr22:38083916-38084999:+
Genomic location(hg38): chr22:37687909-37688992:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancerous specimens; paracancerous specimens
Cell lines:

SiHa; CaSki; C-4I; C-33A; SW756; HeLa; End1/E6E7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HIF-1alpha / HIF1A
Associated microRNA: hsa-miR-217
Biological function: Promotes cervical cancer cell viability and colony proliferation, migration/invasion (metastasis-related phenotypes), and inhibits apoptosis.
Molecular mechanism: Acts as a ceRNA to sponge hsa-miR-217, thereby upregulating HIF-1alpha expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); HIF-1 signaling (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; RNA Pull-Down; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0004543 is up-regulated in cervical cancer tissues and cell lines. It promotes proliferation/colony formation and migration/invasion while inhibiting apoptosis by acting as a ceRNA that sponges hsa-miR-217 to upregulate HIF-1alpha.
Confidence score:

0.7045
Other information
Title:

Circular RNA hsa_circ_0004543 Aggravates Cervical Cancer Development by Sponging MicroRNA hsa-miR-217 to Upregulate Hypoxia-Inducible Factor.

Journal: Journal of oncology
Published: 2022
PubMed ID: 35310917
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are included within the article.
Code availability: -