| Expression pattern: |
UP |
| Associated gene: |
MSH2, AGO2 |
| Associated microRNA: |
miR-370-3p |
| Biological function: |
promotes cervical cancer cell proliferation and migration/metastasis ability; promotes cisplatin resistance |
| Molecular mechanism: |
ceRNA mechanism: circEPSTI1 sponges miR-370-3p to upregulate MSH2 (enriched in AGO2/RISC), thereby promoting tumor progression and cisplatin resistance |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circEPSTI1 is up-regulated in cervical cancer tissues and cell lines. It promotes cervical cancer cell proliferation and migration and increases cisplatin resistance by acting as a ceRNA that sponges miR-370-3p to upregulate MSH2. |
| Confidence score: |
0.8111 |