circRNA basic information
circBase ID: hsa_circ_0001445
Name: hsa_circ_SMARCA5
Synonym: circ-SMARCA5 / circSMARCA5
Host Gene: SMARCA5
Genomic location(hg19): chr4:144464661-144465125:+
Genomic location(hg38): chr4:143543508-143543972:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast tumors; normal tissues adjacent to the tumors
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: CASP3, SP1, CDC42, ITGB1, VEGFA, CDKN1A, YAP1, STAT3, TP53, ERBB2, IGF1R, MYCN, RHOA, SOX2, GSK3B, PIK3CA, MAPK3, MYC, MMP9, YWHAZ, SMARCA5
Associated microRNA: hsa-mir-375, hsa-mir-942
Biological function: tumor suppressive role in breast cancer; may sponge miRNAs and regulate ceRNA networks
Molecular mechanism: ceRNA (miRNA sponging) regulatory mechanism
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Lower expression of hsa_circ_0001445 was significantly associated with age at menarche ˂14 years; higher expression was associated with normal body mass index (BMI) and hair dye avoidance.
Description:

hsa_circ_0001445 is down-regulated in breast cancer tissues versus adjacent normal tissues. The study suggests it may act as a tumor-suppressive circRNA by participating in predicted ceRNA networks (miRNA sponging) that could influence multiple cancer-relevant mRNAs.
Confidence score:

0.348
Other information
Title:

Altered Expression of hsa_circ_0001445 and hsa_circ_0020397 in Breast Cancer Representing Associations with BMI and Reproductive Factors.

Journal: Archives of Iranian medicine
Published: 2022
PubMed ID: 37543909
Study type:

combined biological and clinical study
Data availability: -
Code availability: -