| Expression pattern: |
DN |
| Associated gene: |
MTSS1, AGO2, beta-catenin, GSK3beta |
| Associated microRNA: |
miR-96-5p |
| Biological function: |
Suppresses ovarian cancer cell proliferation, migration, and invasion; inhibits tumor growth and metastasis; represses EMT |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-96-5p to increase MTSS1 expression, thereby inactivating Wnt/beta-catenin signaling (reducing beta-catenin and p-GSK3beta and limiting beta-catenin nuclear translocation). |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; ISH (In Situ Hybridization); Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Agarose Gel Electrophoresis; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; Survival Analysis; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Low circFBXO7 expression was associated with shorter overall survival and relapse-free survival; potential diagnostic and prognostic biomarker. |
| Description: |
circFBXO7 is down-regulated in ovarian cancer and acts as a tumor suppressor. It sponges miR-96-5p to upregulate MTSS1, thereby inactivating Wnt/beta-catenin signaling and inhibiting proliferation, EMT-associated migration/invasion, tumor growth and metastasis. Low circFBXO7 expression correlates with worse patient survival, suggesting prognostic/diagnostic value. |
| Confidence score: |
0.8719 |