circRNA basic information
circBase ID: hsa_circ_0134188
Name: hsa_circ_BBS9
Synonym: hsa_circBBS9
Host Gene: BBS9
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005298
MONDO name: osteoporosis
Disease details: Osteoporosis / OP
Disease DO ID:
 11476
Disease MeSH ID:
 D010024
Disease NCIt ID:
 C3298
Disease ICD11 ID:
 2113001430
Disease OMIM ID:
 166710
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancellous bone; surgical trabecular bone
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: associated with increased expression in osteoporosis patient bone and in PBMC-derived osteoclasts; knockdown in human OCs reduces osteoclast-related gene expression
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection
Clinical significance:

higher expression in cancellous bone from osteoporosis patients versus normal people
Description:

The human circRNA hsa_circ_0134188 (hsa_circBBS9) is elevated in cancellous bone from osteoporosis patients and increased during PBMC-derived osteoclast formation. Knockdown in human osteoclasts reduces osteoclast-related gene expression, supporting translational relevance to osteoporosis.
Confidence score:

0.4128
Other information
Title:

Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system.

Journal: Science advances
Published: 2022
PubMed ID: 35767605
Study type:

combined biological and clinical study
Data availability: -
Code availability: -