| Expression pattern: |
UP |
| Associated gene: |
STIM1, SM22-alpha / SM22a |
| Associated microRNA: |
miR-939 |
| Biological function: |
Regulates VSMC phenotypic differentiation, promotes VSMC proliferation and migration, and inhibits apoptosis. |
| Molecular mechanism: |
circ-SATB2 acts as a sponge for miR-939 and promotes expression of the miR-939 target gene STIM1. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Western Blot; BrdU; Annexin V/PI Flow Cytometry; Transwell Assay |
| Clinical significance: |
circ-SATB2 may be one of the targets for regulating the phenotypic transformation of VSMCs, and may provide a new basis for diagnosis and treatment of cardiovascular diseases. |
| Description: |
In this study, hsa_circ_0007422/circ-SATB2 was up-regulated in proliferative VSMCs. It functions as a miR-939 sponge to upregulate STIM1, thereby promoting VSMC proliferation and migration, inhibiting apoptosis, and regulating phenotypic differentiation. The authors suggest circ-SATB2 may be relevant to the pathogenesis and potential diagnosis or treatment of cardiovascular diseases such as CHD. |
| Confidence score: |
0.5607 |