circRNA basic information
circBase ID: hsa_circ_0078309
Name: hsa_circ_ESR1
Synonym: hsa_circRNA_0078309
Host Gene: ESR1
Genomic location(hg19): chr6:152128453-152201906:+
Genomic location(hg38): chr6:151807318-151880771:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008159
MONDO name: postmenopausal osteoporosis
Disease details: postmenopausal osteoporosis / PMOP
Disease DO ID:
 -
Disease MeSH ID:
 D015663
Disease NCIt ID:
 -
Disease ICD11 ID:
 123797893
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosome; peripheral blood-derived mononuclear cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NFIC, BACH1, CEBPB, POU2F2, ASNS, CYP17A1, DAPK1, HGF, HBB, PRL, TNFAIP6, TFPI2, VWF
Associated microRNA: hsa-miR-566, hsa-miR-4768-3p, hsa-miR-629-3p, hsa-miR-623
Biological function: may regulate bone metabolism of PMOP
Molecular mechanism: ceRNA network (circRNA-miRNA-TF-mRNA regulatory network)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

may serve as potential biomarkers or therapeutic targets for PMOP
Description:

hsa_circ_0078309 (host gene ESR1) is up-regulated in PMOP and included in the final validated ceRNA network, and is suggested to potentially regulate bone metabolism in PMOP via circRNA-miRNA-TF-mRNA regulation.
Confidence score:

0.4032
Other information
Title:

Identification of Serum Exosome-Derived circRNA-miRNA-TF-mRNA Regulatory Network in Postmenopausal Osteoporosis Using Bioinformatics Analysis and Validation in Peripheral Blood-Derived Mononuclear Cells.

Journal: Frontiers in endocrinology
Published: 2022
PubMed ID: 35757392
Study type:

combined biological and clinical study
Data availability: GSE161361; GSE64433; GSE56116
Code availability: -