circRNA basic information
circBase ID: -
Name: hsa_circ_SMARCA5
Synonym: -
Host Gene: SMARCA5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent nontumor mucosa; plasma
Cell lines:

GES-1; MGC803; MKN45; MKN74; AGS; BGC823; SGC7901
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Inhibits gastric cancer cell proliferation, migration, and invasion (tumor-suppressive effect).
Molecular mechanism: -
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; ROC Analysis; Survival Analysis; Transfection; CCK8; Transwell Assay; Cohort Study
Clinical significance:

Low circSMARCA5 expression was associated with poorer overall survival and disease-free survival and circSMARCA5 showed diagnostic value with AUC 0.806.
Description:

circSMARCA5 is down-regulated in gastric cancer tissues, cell lines, and patient plasma. Functionally, circSMARCA5 acts as a tumor suppressor by inhibiting proliferation, migration, and invasion of gastric cancer cells. Clinically, low circSMARCA5 is associated with worse OS/DFS and it shows diagnostic potential (AUC 0.806).
Confidence score:

0.7621
Other information
Title:

circSMARCA5 Functions as a Diagnostic and Prognostic Biomarker for Gastric Cancer.

Journal: Disease markers
Published: 2019
PubMed ID: 30956729
Study type:

combined biological and clinical study
Data availability: The datasets used/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -