circRNA basic information
circBase ID: -
Name: hsa_circ_SLC8A1
Synonym: circSLC8A1 / circNCX1
Host Gene: SLC8A1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004994
MONDO name: cardiomyopathy
Disease details: cardiomyopathy
Disease DO ID:
 0050700
Disease MeSH ID:
 D009202
Disease NCIt ID:
 C34830
Disease ICD11 ID:
 282225286
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human heart biopsies
Cell lines:

hiPSC-CM
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: linSLC8A1
Associated microRNA: miR-133a
Biological function: Circular-to-linear ratio (CLR) of circSLC8A1 is decreased in DCM compared to HTX control; experimental depletion of circSLC8A1/linSLC8A1 in hiPSC-CM changes the CLR accordingly.
Molecular mechanism: Deregulation described primarily at the level of circular-to-linear ratio; circSLC8A1 is mentioned as a potential miR-133a sponge (background).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Transfection; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

The circular-to-linear ratio of circSLC8A1 is decreased in DCM compared to HTX control in this pilot patient cohort.
Description:

Using Lexo-circSeq on human heart biopsies, the study reports a decreased circular-to-linear ratio for circSLC8A1 in DCM versus HTX controls. In hiPSC-derived cardiomyocytes, siRNA knockdown of circSLC8A1 or linSLC8A1 alters the CLR in the expected direction, supporting assay sensitivity and circ/lin balance changes.
Confidence score:

0.4997
Other information
Title:

Targeted Analysis of circRNA Expression in Patient Samples by Lexo-circSeq.

Journal: Frontiers in molecular biosciences
Published: 2022
PubMed ID: 35755822
Study type:

combined biological and clinical study
Data availability: BioProject PRJNA825392
Code availability: -