| Expression pattern: |
DN |
| Associated gene: |
ACVRL1, Ago2 |
| Associated microRNA: |
miR-375 |
| Biological function: |
Suppresses proliferation and migration; promotes apoptosis; inhibits tumor growth in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-375, relieving repression of ACVRL1 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
may be a promising biomarker and gene target for LUAD treatment |
| Description: |
hsa_circ_0129047 is down-regulated in LUAD tissues and cell lines and acts as a tumor suppressor. It primarily localizes to the cytoplasm and inhibits LUAD cell viability and migration while promoting apoptosis, and it suppresses xenograft tumor growth. Mechanistically, it sponges miR-375 to de-repress ACVRL1, forming the hsa_circ_0129047/miR-375/ACVRL1 axis. |
| Confidence score: |
0.7785 |