| Expression pattern: |
UP |
| Associated gene: |
EZH2 |
| Associated microRNA: |
miR-506-3p |
| Biological function: |
Promotes HCC cell proliferation/survival and migration/invasion/metastasis; inhibits apoptosis; promotes tumor xenograft growth and lung metastasis. |
| Molecular mechanism: |
Acts as a ceRNA that sponges miR-506-3p, thereby upregulating EZH2 expression; supported by luciferase reporter and RNA pull-down assays. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; BrdU; CCK8; TUNEL; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
May be a potential diagnostic biomarker and therapeutic target for HCC. |
| Description: |
circSYPL1 is upregulated in HCC tissues/cell lines and promotes malignant phenotypes (proliferation, invasion/metastasis) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-506-3p to increase EZH2 expression, and perturbing miR-506-3p or EZH2 reverses circSYPL1-driven effects. |
| Confidence score: |
0.7552 |