circRNA basic information
circBase ID: hsa_circ_0000390
Name: hsa_circ_FGD4
Synonym: -
Host Gene: FGD4
Genomic location(hg19): chr12:32760890-32764217:+
Genomic location(hg38): chr12:32607956-32611283:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent normal tissues
Cell lines:

GES-1-T; HGC-27; MGC-803
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: AGO2, ATF3, BTG2, DUSP1, EGR1, FGF2, FOSB, GNAI1, GNAO1, GNAZ, GNG7, ITPKB, ITPR1, JUND, NR4A3, PRKCB
Associated microRNA: -
Biological function: May function as ceRNA (miRNA sponge) in gastric cancer; modulates hub gene expression; explored as part of circRNA-miRNA-mRNA networks for GC pathogenesis/therapy strategy.
Molecular mechanism: ceRNA mechanism via predicted MREs and AGO2 binding; circRNA-miRNA-mRNA regulatory network.
Biological pathway or process:

ceRNA regulation (other); MAPK (other); PI3K/AKT (other)
Detected method:
Q
S
M
Validation methods:

Microarray; RNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Transfection
Clinical significance:

-
Description:

hsa_circ_0000390 is down-regulated in gastric cancer tissues and is predominantly localized in the cytoplasm. The study suggests it may act as a ceRNA by sponging miRNAs (with predicted MREs and AGO2 binding) within circRNA-miRNA-mRNA networks that relate to MAPK and PI3K-AKT pathway-enriched target genes.
Confidence score:

0.6223
Other information
Title:

Identification of circRNA-miRNA-mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer.

Journal: Journal of translational medicine
Published: 2021
PubMed ID: 34049561
Study type:

combined biological and clinical study
Data availability: GSE100170; PMID: 27986464; 10.1186/s12967-021-02903-5
Code availability: -