circRNA basic information
circBase ID: hsa_circ_0001492
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr5:65284462-65290692:+
Genomic location(hg38): chr5:65988634-65994864:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; serum-derived exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CEA, NSE
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Serum and serum exosomal hsa_circ_0001492 showed diagnostic value for LUAD and decreased after tumor surgical resection; exosomal hsa_circ_0001492 correlated with higher stage and with CEA and NSE levels.
Description:

hsa_circ_0001492 is up-regulated in LUAD patient serum and serum-derived exosomes and decreases after tumor resection. It shows diagnostic potential (ROC AUC reported), and exosomal levels are associated with more aggressive clinicopathologic features and correlate with CEA and NSE.
Confidence score:

0.459
Other information
Title:

Serum and Serum Exosomal CircRNAs hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 as Diagnostic Biomarkers for Lung Adenocarcinoma.

Journal: Frontiers in oncology
Published: 2022
PubMed ID: 35747792
Study type:

clinical study
Data availability: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Code availability: -