circRNA basic information
circBase ID: -
Name: hsa_circ_SLC25A16
Synonym: circSLC25A16
Host Gene: SLC25A16
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005252
MONDO name: heart failure
Disease details: heart failure / HF
Disease DO ID:
 -
Disease MeSH ID:
 D006333
Disease NCIt ID:
 C50577
Disease ICD11 ID:
 1458683894
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

left ventricle tissue
Cell lines:

Primary human cardiomyocytes (HCM)
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation
Clinical significance:

-
Description:

circSLC25A16 was selected for additional validation of circular features (RNase R resistance, back-splice confirmation, localization) in human heart-related experiments, but its HF-related expression direction and functional mechanism were not individually detailed in the provided text.
Confidence score:

0.5909
Other information
Title:

Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs.

Journal: Basic research in cardiology
Published: 2022
PubMed ID: 35737129
Study type:

combined biological and clinical study
Data availability: Sequencing data generated in this study are available from the corresponding author upon reasonable request.
Code availability: http://rnaeditor.uni-frankfurt.de/