circRNA basic information
circBase ID: hsa_circ_0000907
Name: hsa_circ_MYO9B
Synonym: circMYO9B
Host Gene: MYO9B
Genomic location(hg19): chr19:17212469-17213367:+
Genomic location(hg38): chr19:17101659-17102557:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005148
MONDO name: type 2 diabetes mellitus
Disease details: Type 2 diabetes mellitus / T2DM
Disease DO ID:
 9352
Disease MeSH ID:
 D003924
Disease NCIt ID:
 C26747
Disease ICD11 ID:
 119724091
Disease OMIM ID:
 125853
Species: Human
Species details: Homo sapiens
Tissue specimen:

skin samples from the acute wounds; skin samples from the DFs; normal kidneys; kidneys; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: May play important roles in the onset, occurrence and development of T2DM and its complications.
Molecular mechanism: Predicted circRNA-miRNA-mRNA and circRNA-miRNA-hub gene regulatory network, consistent with a potential miRNA sponge/ceRNA mechanism.
Biological pathway or process:

PI3K/AKT (other); NF-kappaB (other); VEGF/VEGFR (other); angiogenesis (other); proliferation (other); inflammation (other); ceRNA regulation (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Provides new insight into the molecular mechanism of and therapeutic target for T2DM and its complications.
Description:

hsa_circ_0000907/circMYO9B was identified by integrated GEO microarray analysis as one of four key circRNAs in a predicted T2DM-associated circRNA-miRNA-mRNA and circRNA-miRNA-hub gene regulatory network. The study suggests it may be involved in T2DM occurrence and development, but experimental validation beyond bioinformatics analysis was not performed.
Confidence score:

0.1768
Other information
Title:

Identification of a potentially functional circRNA-miRNA-mRNA regulatory network in type 2 diabetes mellitus by integrated microarray analysis.

Journal: Minerva endocrinology
Published: 2024
PubMed ID: 33792237
Study type:

bioinformatics study
Data availability: GSE114248; GSE51674; GSE95849; GEO; Minerva Endocrinol-3370_Supplementary Digital Material1_V2_2020-10-07.docx
Code availability: -