| Expression pattern: |
UP |
| Associated gene: |
MET |
| Associated microRNA: |
miR449a |
| Biological function: |
promotes migration and invasion; promotes metastasis/progression of HCC |
| Molecular mechanism: |
ceRNA mechanism: circPTGR1 sponges miR449a to facilitate MET expression |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Luciferase Reporter Assay; Transfection; Transwell Assay; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Western Blot |
| Clinical significance: |
Upregulated in serum exosomes from HCC patients and associated with clinical stage and prognosis; high circPTGR1 expression indicates worse disease-free survival |
| Description: |
hsa_circ_0008043 (circPTGR1 isoform) is enriched in HCC cell-derived exosomes and is upregulated in serum exosomes from HCC patients. It promotes HCC cell migration/invasion and metastasis by sponging miR449a to increase MET expression, and higher exosomal expression is associated with worse disease-free survival. |
| Confidence score: |
0.8162 |