| Expression pattern: |
UP |
| Associated gene: |
MYLK, ACSM2A, RNF213 |
| Associated microRNA: |
hsa-miR-876-5p, hsa-miR-452-3p, hsa-miR-3167, hsa-miR-143-3p, hsa-miR-130b-5p |
| Biological function: |
- |
| Molecular mechanism: |
Predicted ceRNA networks (circANKRD12-hsa-miR-876-5p-MYLK; circANKRD12-hsa-miR-130b-5p-ACSM2A/RNF213) |
| Biological pathway or process: |
ceRNA regulation (other); mitochondrial function (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
ROC curves uncovered that they have great sensitivity and specificity in the determination of MI. |
| Description: |
circANKRD12 is up-regulated in MI peripheral blood and validated by RT-qPCR. The study predicts ceRNA axes involving hsa-miR-876-5p/MYLK and hsa-miR-130b-5p/ACSM2A-RNF213, potentially linking it to contractile regulation and mitochondrial-related activities, and it has diagnostic potential by ROC analysis. |
| Confidence score: |
0.6957 |