circRNA basic information
circBase ID: hsa_circ_0000615
Name: hsa_circ_ZNF609
Synonym: circZNF609 / circ-ZNF609
Host Gene: ZNF609
Genomic location(hg19): chr15:64791491-64792365:+
Genomic location(hg38): chr15:64499292-64500166:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005068
MONDO name: myocardial infarction
Disease details: myocardial infarction / MI
Disease DO ID:
 5844
Disease MeSH ID:
 D009203
Disease NCIt ID:
 C27996
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

AC16
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: WDR7
Associated microRNA: hsa-miR-644a, hsa-miR-4303, hsa-miR-221-5p, hsa-miR-1260b, hsa-miR-1247-5p
Biological function: -
Molecular mechanism: Predicted ceRNA network (circZNF609-hsa-miR-221-5p-WDR7)
Biological pathway or process:

ceRNA regulation (other); lipid metabolism (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; RNA-seq
Clinical significance:

ROC curves uncovered that they have great sensitivity and specificity in the determination of MI.
Description:

circZNF609 is up-regulated in MI peripheral blood and validated by RT-qPCR. The study predicts a circZNF609-hsa-miR-221-5p-WDR7 ceRNA axis that may relate to LDL/lipid metabolism, and circZNF609 has diagnostic potential by ROC analysis.
Confidence score:

0.6957
Other information
Title:

The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing.

Journal: Frontiers in cardiovascular medicine
Published: 2022
PubMed ID: 35734281
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fcvm.2022.810257/full#supplementary-material
Code availability: -