| Expression pattern: |
UP |
| Associated gene: |
GREM1 |
| Associated microRNA: |
hsa-miR-103b, hsa-miR-1255b-2-3p, hsa-miR-1323, hsa-miR-548a-3p, hsa-miR-1251-5p |
| Biological function: |
- |
| Molecular mechanism: |
Predicted ceRNA (miRNA sponge) network involvement in MI |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
ROC curves uncovered that they have great sensitivity and specificity in the determination of MI. |
| Description: |
circTMEM165 is up-regulated in peripheral blood of MI patients and was validated by RT-qPCR. The study predicts a ceRNA mechanism where circTMEM165 may sponge hsa-miR-548a-3p to influence GREM1-related processes, and it shows diagnostic potential via ROC analysis. |
| Confidence score: |
0.6957 |