| Expression pattern: |
UP |
| Associated gene: |
TRIM66 |
| Associated microRNA: |
miR-625-5p |
| Biological function: |
promotes proliferation, migration, invasion and angiogenesis, and inhibits apoptosis in osteosarcoma cells; promotes tumor formation in vivo |
| Molecular mechanism: |
circ_0051079 sponges miR-625-5p to upregulate TRIM66, thereby activating Wnt/beta-catenin signaling |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Circ_0051079 expression was significantly associated with tumor-node-metastasis stage and tumor size of OS patients. |
| Description: |
circ_0051079 is up-regulated in osteosarcoma tissues and cell lines and promotes malignant behaviors (proliferation, migration/invasion, and angiogenesis) while inhibiting apoptosis. Mechanistically, it sponges miR-625-5p to increase TRIM66 expression and activate Wnt/beta-catenin signaling, and its silencing suppresses xenograft tumor growth. |
| Confidence score: |
0.7597 |