| Expression pattern: |
UP |
| Associated gene: |
SIAH1, CCNB1 |
| Associated microRNA: |
miR-223 |
| Biological function: |
Inhibits trophoblast proliferation and invasion; induces G0/G1 cell cycle arrest |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-223, relieving repression of SIAH1 and thereby inhibiting CCNB1 nuclear translocation |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); cell cycle (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Northern Blot; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; BrdU; Transwell Assay; Cell Cycle Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In spontaneous abortion, circ-CCNB1 is up-regulated in villous tissues and suppresses trophoblast proliferation and invasion while promoting G0/G1 arrest. Mechanistically, circ-CCNB1 sponges miR-223 to increase SIAH1, which contributes to reduced CCNB1 nuclear translocation. |
| Confidence score: |
0.8288 |