circRNA basic information
circBase ID: hsa_circ_0071410
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr4:169812072-169837178:+
Genomic location(hg38): chr4:168890921-168916027:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002203
MONDO name: constipation disorder
Disease details: Slow transit constipation / STC
Disease DO ID:
 -
Disease MeSH ID:
 D003248
Disease NCIt ID:
 C37930
Disease ICD11 ID:
 502284069
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

colon tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SYT2
Associated microRNA: hsa-miR-149-5p
Biological function: -
Molecular mechanism: potential ceRNA network via binding hsa-miR-149-5p to regulate SYT2
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0071410 is significantly down-regulated in STC colon tissues and was validated by qRT-PCR. Bioinformatics predictions suggest a potential ceRNA relationship hsa_circ_0071410-hsa-miR-149-5p-SYT2 that may relate to neuromuscular junction/smooth muscle function in STC.
Confidence score:

0.4032
Other information
Title:

Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.

Journal: Disease markers
Published: 2022
PubMed ID: 35730015
Study type:

combined biological and clinical study
Data availability: PRJNA826640
Code availability: -