circRNA basic information
circBase ID: hsa_circ_0035431
Name: hsa_circ_CGNL1
Synonym: circRNA_10156
Host Gene: CGNL1
Genomic location(hg19): chr15:57730182-57734676:+
Genomic location(hg38): chr15:57437984-57442478:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: HBV-related liver cancer
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver cancer tissues; matched pericancerous tissues / matched paracancerous tissues
Cell lines:

HepG2; Huh7; L02
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Akt1
Associated microRNA: miR-149-3p
Biological function: promotes liver cancer cell proliferation
Molecular mechanism: Acts as a miRNA sponge for miR-149-3p to regulate Akt1 expression.
Biological pathway or process:

proliferation (promotes); PI3K/AKT (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Bioinformatics Analysis; Transfection; CCK8; Clinical Sample Validation
Clinical significance:

-
Description:

circRNA_10156 is up-regulated in HBV-related liver cancer tissues and in HepG2/Huh7 cells. Knockdown of circRNA_10156 increases miR-149-3p, decreases Akt1, and suppresses liver cancer cell proliferation, supporting a circRNA_10156/miR-149-3p/Akt1 regulatory axis.
Confidence score:

0.6432
Other information
Title:

Circular RNA Expression Profiles and the Pro-tumorigenic Function of CircRNA_10156 in Hepatitis B Virus-Related Liver Cancer.

Journal: International journal of medical sciences
Published: 2020
PubMed ID: 32624692
Study type:

combined biological and clinical study
Data availability: -
Code availability: -