| Expression pattern: |
DN |
| Associated gene: |
YTHDC1, RBM5, FUS, CSTF2T, DDX54, DKC1, PTBP1, FBL |
| Associated microRNA: |
hsa-miR-132-5p, hsa-miR-143-5p, hsa-miR-128-1-5p |
| Biological function: |
Potential ceRNA involved in cervical cancer progression; hsa-ESR1_0014-hsa-miR-143-5p was proposed as an interaction with potential impact on lipid metabolism and fatty acid synthesis. |
| Molecular mechanism: |
Predicted ceRNA mechanism and predicted RBP interactions. |
| Biological pathway or process: |
ceRNA regulation (other); lipid metabolism (other) |
| Detected method: |
S
|
| Validation methods: |
Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
Potential biomarker and therapeutic target for cervical cancer progression. |
| Description: |
circRNA4400/hsa-ESR1_0014 was identified as a down-regulated DE circRNA in HSIL and CSCC relative to HPV-positive normal cervical epithelium. It was predicted to interact with hsa-miR-132-5p, hsa-miR-143-5p and hsa-miR-128-1-5p, with the hsa-ESR1_0014-hsa-miR-143-5p pair proposed to affect lipid metabolism and fatty acid synthesis. |
| Confidence score: |
0.1768 |