circRNA basic information
circBase ID: hsa_circ_0092857
Name: hsa_circ_EIF3A
Synonym: -
Host Gene: EIF3a
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

A549; A549/DDP
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: RBPs
Associated microRNA: -
Biological function: Associated with cisplatin drug sensitivity (cisplatin resistance) in lung cancer cells; related to translation regulation
Molecular mechanism: Likely involved in RBPs-mediated biological processes rather than miRNA sponge (not accumulated in AGO2 pellet); predicted circEIF3as/RBPs interaction network; low coding potential
Biological pathway or process:

drug resistance (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Transfection; CCK8; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0092857 is differentially expressed between A549 and cisplatin-resistant A549/DDP lung cancer cells. Its downregulation alters cisplatin resistance, and the study suggests an RBP-related mechanism connected to translation regulation with little evidence for AGO2/miRNA-sponge activity.
Confidence score:

0.6579
Other information
Title:

Circular RNA screening from EIF3a in lung cancer.

Journal: Cancer medicine
Published: 2019
PubMed ID: 31197975
Study type:

biological research
Data availability: All data generated or analyzed during this study are included in this published article (and its Supplementary Information files).
Code availability: -