circRNA basic information
circBase ID: -
Name: hsa_circ_FUNDC1
Synonym: circular RNA FUNDC1 (circFUNDC1) / circFUNDC1
Host Gene: FUNDC1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 1060198
MONDO name: ischemic stroke
Disease details: ischemic stroke / IS
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NLR
Associated microRNA: -
Biological function: Predicts early neurological deterioration and worse neurological severity; associated with shorter post-stroke survival.
Molecular mechanism: Mechanism not experimentally defined; discussion suggests linkage to host gene FUNDC1 and hypoxia-induced mitophagy/autophagy.
Biological pathway or process:

autophagy (other); mitochondrial function (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Circulating circFUNDC1 predicts early neurological deterioration and differentiates 18-month survival between high vs low expression groups in AIS.
Description:

circFUNDC1 is elevated in plasma of AIS patients across TOAST subtypes and is higher in END than non-END cases. Higher circFUNDC1 is associated with greater neurological deficit scores and predicts shorter 18-month post-stroke survival, supporting its potential as an admission blood biomarker for acute-phase outcome and long-term prognosis.
Confidence score:

0.5339
Other information
Title:

Circular RNA FUNDC1 for Prediction of Acute Phase Outcome and Long-Term Survival of Acute Ischemic Stroke.

Journal: Frontiers in neurology
Published: 2022
PubMed ID: 35720103
Study type:

clinical study
Data availability: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Code availability: -