| Expression pattern: |
UP |
| Associated gene: |
TCF12 |
| Associated microRNA: |
miR-337-3p |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, invasion and metastasis, and suppresses apoptosis. |
| Molecular mechanism: |
circ_0000388 acts as a sponge for miR-337-3p and promotes TCF12 expression through the miR-337-3p/TCF12 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; TUNEL; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot |
| Clinical significance: |
Upregulated circ_0000388 was correlated with unfavorable pathological indexes, including FIGO stage, lymph node metastasis, and depth of invasion, and could potentially be used as a diagnostic biomarker and therapy target. |
| Description: |
circ_0000388 is upregulated in cervical cancer tissues and cell lines and is associated with advanced clinicopathological features. Functionally, it promotes proliferation, migration, invasion and metastasis while inhibiting apoptosis of cervical cancer cells. Mechanistically, circ_0000388 sponges miR-337-3p to increase TCF12 expression, forming a circ_0000388/miR-337-3p/TCF12 oncogenic axis. |
| Confidence score: |
0.7045 |