circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF292
Synonym: cZNF292
Host Gene: ZNF292
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004781
MONDO name: acute myocardial infarction
Disease details: acute myocardial infarction / AMI
Disease DO ID:
 9408
Disease MeSH ID:
 -
Disease NCIt ID:
 C35204
Disease ICD11 ID:
 1334938734
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

whole blood; serum; plasma
Cell lines:

HUVEC; hESC line H9; hESC-CM
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ZNF292
Associated microRNA: -
Biological function: Biomarker for AMI diagnosis; promotes apoptosis in endothelial cells and cardiomyocytes under OGD/R (knockdown attenuates apoptosis).
Molecular mechanism: Not specified; functional evidence via siRNA knockdown in OGD/R model.
Biological pathway or process:

apoptosis (promotes); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; TUNEL; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

cZNF292 combined with clinical information can predict AMI effectively and separates AMI from non-AMI/UA/non-ACS in validation cohort.
Description:

Circulating cZNF292 is up-regulated in whole blood of AMI (and ACS) patients and, when combined with basic clinical information, improves diagnostic performance in machine-learning/logistic-regression models. Functionally, cZNF292 is induced by OGD/R in endothelial cells and hESC-derived cardiomyocytes, and its knockdown reduces apoptosis, suggesting a pro-apoptotic role under ischemia/reperfusion-like stress.
Confidence score:

0.7468
Other information
Title:

Diagnosis of acute myocardial infarction using a combination of circulating circular RNA cZNF292 and clinical information based on machine learning.

Journal: MedComm
Published: 2023
PubMed ID: 37323876
Study type:

combined biological and clinical study
Data availability: The data for this study are available by contacting the corresponding author upon reasonable request.
Code availability: -