circRNA basic information
circBase ID: -
Name: hsa_circ_PTPN22
Synonym: circPTPN22
Host Gene: PTPN22
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005002
MONDO name: chronic obstructive pulmonary disease
Disease details: chronic obstructive pulmonary disease / COPD
Disease DO ID:
 3083
Disease MeSH ID:
 D029424
Disease NCIt ID:
 C3199
Disease ICD11 ID:
 133207228
Disease OMIM ID:
 606963
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: Predicted to function through miRNA sponging (ceRNA network) in COPD.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circPTPN22 is significantly up-regulated in peripheral blood from COPD patients. It was used to construct a predicted circRNA-miRNA-mRNA network, indicating a potential ceRNA (miRNA sponge) role in COPD.
Confidence score:

0.4032
Other information
Title:

Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease.

Journal: Respiratory research
Published: 2022
PubMed ID: 35690768
Study type:

combined biological and clinical study
Data availability: GSE198740
Code availability: -