| Expression pattern: |
UP |
| Associated gene: |
NEUROD1 |
| Associated microRNA: |
miR-127-5p |
| Biological function: |
Promotes NB cell proliferation, migration, invasion and tumorigenicity, and suppresses apoptosis. |
| Molecular mechanism: |
Circ_0135889 functions as a sponge for miR-127-5p and positively regulates NEUROD1 expression through a ceRNA mechanism. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Transfection; MTS; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Circ_0135889 expression in pediatric NB tumors was associated with tumor size and International Neuroblastoma Staging System staging, suggesting potential therapeutic relevance. |
| Description: |
Hsa_circ_0135889 is an AGO2-derived human circRNA upregulated in neuroblastoma tissues and cell lines. It promotes proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis, acting through a circ_0135889/miR-127-5p/NEUROD1 ceRNA axis. Its expression is associated with tumor size and INSS stage, supporting its potential as a therapeutic target. |
| Confidence score: |
0.7759 |