circRNA basic information
circBase ID: -
Name: hsa_circ_RERE
Synonym: hsa_circRNA_100033
Host Gene: RERE
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005147
MONDO name: type 1 diabetes mellitus
Disease details: type 1 diabetes
Disease DO ID:
9744
Disease MeSH ID:
D003922
Disease NCIt ID:
C2986
Disease ICD11 ID:
1651053999
Disease OMIM ID:
222100
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells / PBMCs; venous blood

Cell lines:

-

In vivo animal model:

-

circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Serves as a potential differential diagnostic biomarker for T1D and helps distinguish T1D from LADA, T2D, and NGT controls; functional effects were not experimentally tested.
Molecular mechanism: Not experimentally determined; the study suggests possible roles in immunity, metabolism, and diabetes complications based on host gene context.
Biological pathway or process:

not specified

Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis

Clinical significance:

Potential differential diagnostic biomarker for T1D; logistic LASSO models including hsa_circRNA_100033 helped distinguish T1D from LADA, T2D, and NGT controls.

Description:

hsa_circRNA_100033 was significantly downregulated in T1D and showed an incremental decrease across the diabetes spectrum from NGT to T2D/LADA to T1D. It was validated by RT-qPCR in clinical PBMC samples and contributed to logistic LASSO diagnostic models, especially for distinguishing T1D from LADA and T2D.

Confidence score:

0.5963

Other information
Title:

Hsa_circRNA_405498 and hsa_circRNA_100033 Serve as Potential Biomarkers for Differential Diagnosis of Type 1 Diabetes.

Journal: The Journal of clinical endocrinology and metabolism
Published: 2024
PubMed ID: 38157408
Study type:

combined clinical and bioinformatics study

Data availability: Some or all data sets generated during and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.
Code availability: -