| Expression pattern: |
DN |
| Associated gene: |
SOSTDC1, Ki67, Bax, MMP-2 |
| Associated microRNA: |
miR-586 |
| Biological function: |
Exosomal circ_0001190 overexpression inhibits GC cell vitality, proliferation, angiogenesis, migration, invasion and xenograft tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
Exosomal circ_0001190 functions as a miR-586 sponge to regulate SOSTDC1 expression through the circ_0001190/miR-586/SOSTDC1 axis. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); angiogenesis (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Tube Formation Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low abundance of circ_0001190 was linked with poor prognosis of GC, making it a possible marker of GC; exosomal circ_0001190 overexpression proposed a potential targeted therapy for GC cure. |
| Description: |
circ_0001190 is downregulated in gastric cancer tissues, GC cell lines, and patient plasma/serum exosomes, and low expression is associated with worse survival. Exosomal circ_0001190 suppresses GC progression by sponging miR-586 and increasing SOSTDC1, thereby inhibiting proliferation, angiogenesis, migration, invasion and tumor growth while promoting apoptosis. The study suggests circ_0001190 may be a prognostic marker and potential therapeutic target in GC. |
| Confidence score: |
0.8354 |