| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Serves as a potential differential diagnostic biomarker for T1D and helps distinguish T1D from LADA, T2D, and NGT controls; functional effects were not experimentally tested. |
| Molecular mechanism: |
Not experimentally determined; the study suggests possible roles in immunity, metabolism, and diabetes complications based on host gene context. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential differential diagnostic biomarker for T1D; logistic LASSO models including hsa_circRNA_100033 helped distinguish T1D from LADA, T2D, and NGT controls. |
| Description: |
hsa_circRNA_100033 was significantly downregulated in T1D and showed an incremental decrease across the diabetes spectrum from NGT to T2D/LADA to T1D. It was validated by RT-qPCR in clinical PBMC samples and contributed to logistic LASSO diagnostic models, especially for distinguishing T1D from LADA and T2D. |
| Confidence score: |
0.5963 |