circRNA basic information
circBase ID: hsa_circ_0084904
Name: hsa_circ_KIAA1429
Synonym: circ_0084904
Host Gene: -
Genomic location(hg19): chr8:95518727-95524317:-
Genomic location(hg38): chr8:94506499-94512089:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical primary tumors; adjacent normal cervical tissues; cervical squamous cell carcinoma tissues; paired adjacent nontumor cervical tissues; xenograft tumors
Cell lines:

Ect1/E6E7; HeLa; C-33A; SiHa; ME-180; Caski
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MAL2, Ago2, RISCs
Associated microRNA: miR-802
Biological function: Promotes cervical cancer cell colony formation, cell cycle progression, migration, invasion, EMT, glycolysis, and tumor growth, and inhibits apoptosis.
Molecular mechanism: circ_0084904 acts as an oncogenic ceRNA by binding miR-802, relieving miR-802-mediated suppression of MAL2 and thereby increasing MAL2 expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); glycolysis (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Transfection; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); ROC Analysis
Clinical significance:

circ_0084904 showed high diagnostic value in CC tissues compared with normal cervical tissues; silencing circ_0084904 might represent a promising targeted therapy for CC.
Description:

circ_0084904 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes malignant phenotypes including proliferation, cell cycle progression, migration, invasion, EMT, glycolysis, and tumor growth while suppressing apoptosis, mainly through the circ_0084904/miR-802/MAL2 regulatory axis. Its high diagnostic value and functional inhibition by silencing suggest potential clinical utility as a biomarker and therapeutic target.
Confidence score:

0.8353
Other information
Title:

The novel circ_0084904/miR-802/MAL2 axis promotes the development of cervical cancer.

Journal: Reproductive biology
Published: 2022
PubMed ID: 35033901
Study type:

combined biological and clinical study
Data availability: GSE102686; Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j. repbio.2021.100600
Code availability: -