circRNA basic information
circBase ID: -
Name: hsa_circ_KATNAL1
Synonym: hsa_circ_008068
Host Gene: KATNAL1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tumour tissues; normal lung tissues; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-4686, hsa-miR-4778-3p, hsa-miR-1236-3p
Biological function: Diagnostic biomarker for early-stage LUAD (tissues and circulating plasma).
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Upregulated in LUAD tumour tissues and circulating plasma and shows diagnostic value by ROC/AUC; positively associated with tumour differentiation, tumour size and CEA.
Description:

hsa_circ_008068 is significantly up-regulated in stage I LUAD tumour tissues and in circulating plasma compared with controls. It has diagnostic value for early-stage LUAD based on ROC/AUC analysis and is associated with clinicopathologic indicators including tumour differentiation, tumour size and CEA.
Confidence score:

0.5963
Other information
Title:

Circular RNAs Hsa_circ_101555 and Hsa_circ_008068 as Diagnostic Biomarkers for Early-Stage Lung Adenocarcinoma.

Journal: International journal of general medicine
Published: 2022
PubMed ID: 35707741
Study type:

combined biological and clinical study
Data availability: -
Code availability: -