| Expression pattern: |
UP |
| Associated gene: |
predicted target genes |
| Associated microRNA: |
hsa-miR-130b-5p, hsa-miR-367-5p, hsa-miR-128-3p, hsa-miR-501-5p, hsa-miR-381-3p |
| Biological function: |
Upregulated in FOLFOX-resistant CRC cell model and FFPE CRC samples; proposed as a promising biotarget related to chemoresistance. |
| Molecular mechanism: |
Predicted circRNA-miRNA-target gene regulatory mechanism involving five predicted miRNAs and target genes enriched in Pathways in Cancer. |
| Biological pathway or process: |
chemoresistance (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Promising biotarget for chemoresistant colorectal cancer; upregulated in clinical FFPE CRC samples. |
| Description: |
hsa circ 32883 was upregulated in chemoresistant HCT116 CRC cells and in FFPE CRC clinical samples from chemotherapy responders/nonresponders. The study proposed it as a promising biotarget and predicted a circRNA-miRNA-target gene regulatory relationship, especially involving hsa-miR-501-5p and genes enriched in cancer-related pathways. |
| Confidence score: |
0.5135 |